UV Spectrophotometric Evaluation of Drug Solubility Profiles in Varied Pharmaceutical Formulations

Abstract

This study aimed to develop a method for comparing the solubility profiles of three distinct brands of Diclofenac Sodium formulations using UV spectrophotometry. The analysis was conducted under optimal dissolution conditions, employing 900 mL of pH 7.4 phosphate buffer as the dissolution medium, with a paddle apparatus (Type II) set to 100 revolutions per minute. A wavelength of 282.2 nm was used for the UV spectrophotometric measurement of drug release. The proposed method demonstrated a drug release percentage close to 100%, aligning well with the labeled claims of the marketed tablet formulations. This approach provides a simple, precise, and reliable technique for comparative analysis of solubility profiles across various formulations, supporting pharmaceutical quality control and formulation optimization.