Biginelli Reaction- A Green Chemistry Approach for Synthesis of Tetrahydro Pyrimidine Derivatives

Abstract

The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea, and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of tetrahydro pyrimidine derivatives and related heterocyclic compounds. Green chemistry is an eco-friendly synthetic pathway for pollution-free synthesis and manufacturing of the product. The tetrahydro pyrimidine and its derivatives are highly significant because they generally show diverse medicinal properties, such as calcium channel blockers, antihypertensive and anti-inflammatory agents, andα1-a antagonists. The current review focuses on the green synthesis approach for the synthesis of tetrahydro pyrimidine derivatives via the Biginelli reaction. The review also throws light on recent advances in Biginelli's reaction