Etiology, Risk Factors, and Future Perspectives on Hepatotoxicity Induced by Anti-Tuberculosis Medications

Abstract

Anti-tuberculosis drugs are one of the most common causes of idiosyncratic hepatotoxicity worldwide. Mostly first-line drug therapy of tuberculosis is the reason for hepatotoxicity. isoniazid-induced toxicity is more severe than hepatotoxicity, other factors are also cause of liver toxicity including age, gender, alcohol intake, etc are also responsible for hepatotoxicity. the liver is the main organ for maintaining the internal body environment and idiosyncratic drug toxicity result in death or transplant, therefore prevention method and good treatment for hepatotoxicity is necessary. Considering the hepatoxicity due to antituberculosis drugs are a major cause of liver failure this review throw light on the various anti-tuberculosis drug that produces toxicity, management of hepatotoxicity, and future directions.