Liver X Receptor : A Potential Target for Hypertension

Abstract

The Liver X receptor (LXR) emerges as a key player in the intricate relationship between hypertension and cardiovascular health. According to recent research, LXRs bind to a non-canonical response area in the renin promoter to regulate the transcription of the renin gene, which may have an impact on blood pressure regulation. LXR agonists have also demonstrated potential in lowering the rise in blood pressure brought on by Angiotensin II (Ang II), in part due to their suppression of AT1 and AT2 receptor gene expression. LXRs may potentially affect hypertension via influencing the amounts of TNF and NF-κB. Furthermore, nitrite levels are raised by LXR agonists in both normotensive and hypertensive states. These findings demonstrate how LXR can be targeted at different phases of the management of hypertension, which makes it a compelling therapeutic target for additional research in the area of cardiovascular health.