Comparative Assessment of Drug Solubility Profiles in Various Formulations Using UV Spectrophotometry: A Comprehensive Study

Abstract

This study aimed to establish a technique for comparing the solubility profiles of three distinct brands of Diclofenac Sodium medication formulations using UV Spectrophotometry. Diclofenac Sodium was analyzed using a precise UV spectrophotometric method under optimal dissolution conditions, employing 900 milliliters of pH 7.4 phosphate buffer as the dissolution medium and a paddle (type II) apparatus stirring at 100 revolutions per minute. A detecting wavelength of 282.2 nm was utilized for UV spectrophotometric assessment of drug release. The proposed method demonstrated an anticipated drug release percentage close to 100%, which correlated well with the labeled claim of marketed tablet formulations. This approach offers a straightforward, accurate, and reliable means for comparative analysis of drug solubility profiles in various formulations, aiding in pharmaceutical quality assessment and formulation optimization.